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N2O 4

n-heptane 4

CH4 3

CO2 3

COVID-19 3

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N 2

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N-nitrosodimethylamine (NDMA) 2

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IgG N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age Article

Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang

Engineering 2023, Volume 26, Issue 7,   Pages 99-107 doi: 10.1016/j.eng.2022.12.004

Abstract: However, the usable capacity of IgG N-glycosylation profiles for the risk stratification of cardiovascularThis study aimed to develop a cardiovascular aging index for tracking cardiovascular risk using IgG <N-glycosylation cardiovascular age (GlyCage) index to reflect the deviation from calendar age attributableThe GlyCage index developed in this study can thus be used to track cardiovascular health using IgG N-glycosylationthat IgG N-glycosylation plays a role in the pathogenesis of CVDs.

Keywords： IgG N-glycosylation cardiovascular age     Cardiovascular aging     Immunoglobulin G     Glycosylation     Inflammation    

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Bidirectional Causality Between Immunoglobulin G N-Glycosylation and Metabolic Traits: A Mendelian Randomization Article

Xiaoni Meng, Weijie Cao, Di Liu, Isinta Maranga Elijah, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang

Engineering 2023, Volume 26, Issue 7,   Pages 74-88 doi: 10.1016/j.eng.2022.11.004

Abstract:

Bidirectional causalityAlthough the association between immunoglobulin G (IgG) N-glycosylation andN-glycosylation traits, 72 (including one putatively causal metabolic trait for GP1 (high-density lipoproteinN-glycosylation in one- and two-sample MR studies, respectively (all P < 0.05).N-glycosylation and metabolic traits, possibly revealing a new richness in the biological mechanismbetween IgG N-glycosylation and metabolic traits.

Keywords： Mendelian randomization study     Immunoglobulin G     N-glycosylation     Metabolic traits     Quantitative trait    

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Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle Article

Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc

Engineering 2023, Volume 26, Issue 7,   Pages 108-118 doi: 10.1016/j.eng.2022.10.020

Abstract: The modification of IgG N-glycosylation is considered to be one of the various mechanisms by which sex, IgG N-glycosylation dynamics during the menstrual cycle have not yet been investigated.We observed cyclic periodic changes in the N-glycosylation of IgG in association with the menstrual cycleOn the integrated cohort level, the modeled average menstrual cycle effect on the abundance of IgG N-glycosylationN-glycosylation.

Keywords： N-glycosylation     Immunoglobulin G     Menstrual cycle     Female sex hormones     Estrogen     Progesterone     Testosterone    

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Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation Review

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Engineering 2023, Volume 26, Issue 7,   Pages 17-31 doi: 10.1016/j.eng.2023.03.013

Abstract: In Section 1, we provide a brief overview of the N-glycan's structural organization, andNext, in Section 3, we summarize, systemize, and generalize the results from current N-glycosylationUntil now, such studies have been limited to an analysis of the human blood plasma N-glycomeand the N-glycosylation of immunoglobulin G and transferrin.mechanisms of action and biological targets of genetic variation that have been implicated in human protein N-glycosylation

Keywords： Glycome     Glycans     N-glycosylation     Genomics     Genetics     GWAS    

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Novel Insight into the Etiology of Haff Disease by Mapping the N-Glycome with Orthogonal Mass Article

Si Liu, Yuanyuan Liu, Jiajing Lin, Bi-Feng Liu, Zhenyu He, Xiaomin Wu, Xin Liu

Engineering 2023, Volume 26, Issue 7,   Pages 63-73 doi: 10.1016/j.eng.2022.09.012

Abstract: Profiling of the N-glycome in HD would assist in deciphering the underlying molecular mechanismof the disease, whereas HD-associated glycosylation has never been explored.N-glycome profiles of both serum and serum-derived immunoglobulin G (IgG) in HD were characterizedIt was notable that the changes in the galactosylation and sialylation of IgG1 and IgG2 were subclassOur study reveals the association of differential IgG N-glycosylation with HD, providing new insight

Keywords： Haff disease     Serum     Immunoglobulin G     Glycosylation     Disease pathogenesis    

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Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 258-270 doi: 10.1007/s11684-016-0458-7

Abstract:

The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determinationof a protein’s half-life is dependent on its N-terminal residue.The N-terminal residue serves as the degradation signal of a protein and thus called N-degron.N-degron can be recognized and modifed by several steps of post-translational modifications, such asdifferentiation, chromosomal segregation, genome stability, apoptosis, mitochondrial quality control, cardiovascular

Keywords： N-end rule pathway     Ate1     cardiovascular development     neurogenesis     spermatogenesis     neurodegenerative disorders    

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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract: The effect is better seen as an overall change in the total HepG2 N-glycome, primarily due toWe propose an alternative way to evaluate the N-glycome composition via estimating the overallthe mutual activation of HNF1A–FOXA2 and HNF4A–FOXA2 affecting glyco-genes and protein glycosylation

Keywords： factor 1 alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation    

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Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk betweenIgG sialylation and pDC functions

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 549-561 doi: 10.1007/s11684-022-0965-7

Abstract: Immunoglobulin (IgG) glycosylation affects the effector functions of IgG in a myriad of biological processesautoimmune diseases, including systemic lupus erythematosus (SLE), thus underlining the pathogenic role of glycosylation- and deSia-IgG-treated pDCs.Finally, the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstratedthe sialylation-dependent anti-inflammatory function of IgG.

Keywords： pregnancy     IgG glycome     type I interferon     systemic lupus erythematosus    

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Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 404-418 doi: 10.1007/s11684-014-0379-2

Abstract: In the past several years, the aberrant expressions of miRNAs in the cardiovascular system have beenreported, and the crucial roles of some special miRNAs in heart development and pathophysiology of various cardiovascularThese discoveries not only reveal the functions of circulating miRNAs in cardiovascular system but alsoIn this review, we discuss the potential roles of circulating miRNAs in a variety of cardiovascular diseasesfrom biomarkers to therapeutic targets to clearly understand the roles of circulating miRNAs in cardiovascular

Keywords： microRNA     cardiovascular disease     biomarkers     therapeutic target    

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Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus Article

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Engineering 2023, Volume 26, Issue 7,   Pages 89-98 doi: 10.1016/j.eng.2023.01.006

Abstract: Here, we identified two N-glycans on serum immunoglobulin G (IgG) as excellent diagnostic biomarkersThese two N-glycan biomarkers are specific for diagnosing SLE, as no significant changes inNotably, the two N-glycan biomarkers proved to be autoantibody-independent and all-stage patientThe two N-glycan biomarkers are demonstrated to be located on the Fc region based on fragment-specificOur findings provide insights into efficient population screening based on serum IgG glycosylation and

Keywords： Systemic lupus erythematosus     N-glycans     Diagnostic indicators    

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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract:

Inflammation is important in the pathogenesis and development of cardiovascular diseases.shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations

Zhonghua Sun

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 254-270 doi: 10.1007/s11684-011-0153-7

Abstract: Multislice computed tomography (CT) has been widely used in clinical practice for the diagnosis of cardiovascularThe imaging diagnosis of cardiovascular disease is based on a combination of two-dimensional (2D) andarticle is to present an overview of the diagnostic performance of various 2D and 3D CT visualizations in cardiovascularefficiently using the multislice CT imaging modality for the diagnostic management of patients with cardiovascular

Keywords： cardiovascular disease     multislice computed tomography     three-dimensional reconstruction     diagnosis     visualization    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: The Fc fragment of the IgG-binding protein (FCGBP) was identified as the most promising indicator of

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein    

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Development trend of urban design in “digital age”: Pan-dimensionality and individual-ubiquity

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 3,   Pages 569-575 doi: 10.1007/s11709-021-0735-7

Abstract: The wave of “digital age” featuring digital information is coming.

Keywords： digital age     urban design     multiple objectives     human-computer interaction     pan-dimensionality     individual-ubiquity    

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High-level expression of recombinant IgG1 by CHO K1 platform

Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 376-380 doi: 10.1007/s11705-015-1531-5

Abstract: synthetase (GS) vector was applied to construct a single plasmid to overexpress a monoclonal antibody IgG1The best cell pool of CHO K1/IgG1 was used to screen the top single clone using the limiting dilutionFinally, a high IgG1 production of 780 mg/L was obtained from a batch culture.

Keywords： Chinese hamster ovary (CHO)     monoclonal antibody     IgG1     amplification     cell line development    

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Title Author Date Type Operation

IgG N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age

Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang

Journal Article

Bidirectional Causality Between Immunoglobulin G N-Glycosylation and Metabolic Traits: A Mendelian Randomization

Xiaoni Meng, Weijie Cao, Di Liu, Isinta Maranga Elijah, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang

Journal Article

Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle

Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc

Journal Article

Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Journal Article

Novel Insight into the Etiology of Haff Disease by Mapping the N-Glycome with Orthogonal Mass

Si Liu, Yuanyuan Liu, Jiajing Lin, Bi-Feng Liu, Zhenyu He, Xiaomin Wu, Xin Liu

Journal Article

Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk betweenIgG sialylation and pDC functions

Journal Article

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Journal Article

Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Journal Article

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article

Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations

Zhonghua Sun

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Journal Article

Development trend of urban design in “digital age”: Pan-dimensionality and individual-ubiquity

Journal Article

High-level expression of recombinant IgG1 by CHO K1 platform

Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu

Journal Article